HPV and p53 expression in dysplastic lesions and squamous carcinomas of the oral mucosa

Vol. 46 No. 2, 2005

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Cristiana Simionescu, Cl. Margaritescu, Claudia Valentina Georgescu, M. Surpateanu

We studied 18 premalignant and malignant lesions of the oral mucosa, three dysplasias, and 15 oral squamous carcinomas with varied localizations: lips, palate, and tongue. Immunoassays for HPV were positive in 42.8% of the squamous carcinomas, without correlation with the pattern or the degree of differentiation of the lesions. P53 immunoexpression was positive in two of the three studied cases of dysplasia (66.6%) and in 13 from the 15 cases of squamous carcinomas (86.6%). The p53 immunopositivity in both lesional categories, with a higher rate in carcinomas, indicates the fact that the p53 gene mutations can appear precocious in the oral carcinogenesis, but cannot be used as malign potential prediction factor.

Corresponding author: Cristiana Simionescu, MD, PhD, e-mail: csimionescu2004@yahoo.com

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