Salivary gland basal cell adenomas - immunohistochemical evaluation of four cases and review of the literature

Vol. 46 No. 1, 2005

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Cl. Margaritescu, Veronica Mercut, L. Mogoanta, Maria Florescu, Cristiana Simionescu, Lucia Cionca, Madalina Manea

Objective - evaluate the antigen profile of cellular population from basal cell adenomas. Material and methods - histopathological and immunohistochemical evaluation of four-salivary gland basal cell adenomas; the pathological samples were provided by the Oral Maxilla Facial Surgery Department of the Clinical County Hospital from Craiova. Results - all basal cell adenoma exhibit differentiation toward three cell phenotypes: ductal luminal, basal and myoepithelial. Conclusions - the antigen profile of these tumors closely regard with other variants of salivary gland adenomas, such as pleomorphic adenoma and myoepithelioma. Therefore, we can conclude that these tumors had a common origin, most probably from intercalated ducts and the proportion of those three cellular types, their cytoarhitectural arrangements and the quantity of extracellular matrix production can do the differentiation between them.

Corresponding author: Margaritescu, MD, PhD, e-mail: mclaudiu@umfcv.ro, c_margaritescu@hotmail.com

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