Primitive neuroectodermal tumors of the ovary: a multidecade review of the scientific literature
Vol. 65 No. 1, 2024
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
Tiberiu-Augustin Georgescu, Antonia Carmen Georgescu, Andrei Dennis Voichitoiu, Dragos Cretoiu, Nicolae Suciu, Adriana-Irina Ciuvica
Primitive neuroectodermal tumor (PNET) is a general term used in scientific literature for a heterogeneous group of small round-cell malignant tumors primarily arising from neural crest cells. These are extremely aggressive neoplasms which usually occur within soft tissue or bone of young adults. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare, with only few case reports in scientific literature. Due to being so exceedingly rare, PNETs are frequently misdiagnosed and there are no standard therapeutic guidelines. Young patients seem to have better prognoses and individualized strategy is recommended. Limited data suggests that various gene deletions as well as amplifications may be crucial factors for tumorigenesis and the aggressive behavior of PNET. In this paper, we performed a brief review of all cases of primary ovarian PNETs published in the scientific literature to date, in regard to their clinical, histopathological, and therapeutic aspects, with the aim to provide a more comprehensive understanding of this exceedingly rare pathology.
Corresponding author: Antonia Carmen Georgescu, Assistant Professor, MD, PhD; e-mail: antoniacarmen.georgescu@gmail.com
DOI: 10.47162/RJME.65.1.01 Download PDF Primitive neuroectodermal tumors of the ovary: a multidecade review of the scientific literature PDF
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