The role of gut dysbiosis in endometriosis diagnosis and treatment approaches - case report

Vol. 64 No. 2, 2023


Alexandra Irma Gabriela Bausic, Sanda Maria Cretoiu, Vasilica Bausic, Daniela Roxana Matasariu, Ruxandra Viorica Stanculescu, Elvira Bratila

Background: Endometriosis (EM) is a chronic multifactorial disease characterized by the presence of endometrial tissue outside the uterus. The clear etiopathogenesis of EM is unclear. Increasing evidence was gathered about the crucial involvement of gut microbiota in early stages of the disease, and in its progression. Case presentation: We report the case of a 33-year-old Caucasian woman diagnosed with EM, that presented with painful pelvic (dysmenorrhea, dyspareunia) and gastrointestinal (GI) symptomatology. The patient underwent an intestinal microbiota analysis before the surgical treatment was performed. Discussions: The GI microbiome culture identified high levels of non-pathogen bacteria Escherichia coli, Bifidobacterium, hemolytic E. coli and potential pathogens: Hafnia alvei and Enterobacter cloacae. The mycology culture performed identified the presence of potential pathogens: Candida albicans and C. glabrata. Microscopic examination and polymerase chain reaction (PCR) analysis showed Giardia lamblia in moderate amounts. These findings were compared with the information available in the literature of specialty and they imply that the patient intestinal microbiome is heavily disrupted. Conclusions: There are changes in the microbiota of EM patients in comparison to those not suffering from this disease. The findings addressed in this article characterize the intricate bilateral connection between the microbiota and EM. The goal of future studies ought to be to establish how the microbiome and EM are interconnected by implementing breakthrough diagnostic and treatment strategies.

Corresponding author: Vasilica Bausic, Associate Professor, MD, PhD; e-mail:; Sanda Maria Cretoiu, Associate Professor, MD, PhD; e-mail:

DOI: 10.47162/RJME.64.2.17 Download PDF
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