Nasal polyposis from cystic fibrosis in children - the experience of a single center

Vol. 64 No. 2, 2023

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Gheorghe Iovanescu, Liviu Laurentiu Pop, Daniela Roxana Vintila, Karina Cristina Marin, Carmen Aurelia Mogoanta, Dorela Codruta Lazureanu, Veronica Madalina Boruga, Ioana Mihaela Ciuca

Background: Cystic fibrosis (CF) is the most common monogenic disease, characterized by clinically notable polymorphism. Respiratory disease is the main factor that influences the disease outcome and prognosis of the patient with CF, bacterial infections being responsible for severe exacerbations and rhinosinusitis a difficult complication, besides lung disease. Aim: The aim of the paper was to present a case series of CF-associated nasal polyposis and our management experience, providing new data for nasal and sinus complications. Patients, Materials and Methods: Patients attending the National Cystic Fibrosis Center, Timisoara, Romania, were evaluated for nasal polyposis. Besides clinical examination, endoscopy, and computed tomography (CT) was performed for comprehensive evaluation. Patients with persistent symptoms or with complicated sinusitis underwent surgical approach. Results: Fourteen (18.18%) children were diagnosed with nasal polyposis and had surgery, with positive outcomes. One patient received Omalizumab for an associated, uncontrolled asthma with a subsequent substantial effect with the significant polyp reduction and lack of recurrence. Conclusions: Even if extremely difficult to manage, complicated nasal polyposis CF related might have an improved outcome and better life quality.

Corresponding author: Carmen Aurelia Mogoanta, Associate Professor, MD, PhD; e-mail: carmen_mogoanta@yahoo.com

DOI: 10.47162/RJME.64.2.14 Download PDF
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