Genetic aspects in schizophrenia. Receptoral theories. Metabolic theories

Vol. 61 No. 1, 2020

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Simona Corina Trifu, Anca Vladuti, Antonia Ioana Trifu

Ties between schizophrenia (SCZ) and genetics are undeniably significant issue prone to be discussed in the nowadays psychology. Recent research on this domain focuses more on specific genes and heredity (specifically monozygotic pairs of twins) for diagnosing SCZ, than on environmental influences. SCZ is considered a multifactorial disease, thought to convert from a merger of risk and biological genes and environmental factors that could alter and reshape the trajectory of brain development. On this regard, this review sums up recent and innovative methods of distinguishing schizophrenic features from other mental illnesses in patients, based on chromosomal and genes changes. The term reverse genetics is no longer up to date, being replaced with genome scanning and positional cloning. For many researchers, genome scanning is continuing the reverse of the sensible strategy for detecting various important biological disorders, which may start from the discovery of a protein or any other molecule involved in a biological process, being followed by its gene cloning. Genes being discovered in this manner could become candidate genes for the disease. However, genome scanning occurs through testing each chromosomal segment (or mitochondrial genome) for the counter transmission of the disease.

Corresponding author: Simona Corina Trifu, Lecturer, PhD; e-mail: simonatrifu@yahoo.com

DOI: 10.47162/RJME.61.1.03 Download PDF