Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection

Vol. 61 No. 1, 2020


Andreea-Elena Cirstea, Radu Lucian Buzulica, Daniel Pirici, Mihail Constantin Ceausu, Radu Vasile Iman, Ovidiu-Mircea Gheorghe, Simona Daniela Neamtu, Liliana Stanca, Razvan Ene, Samir Kumar-Singh, Laurentiu Mogoanta

We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinti County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.

Corresponding author: Radu Lucian Buzulica, MD, PhD; e-mail: lucianbuzulica@yahoo.com; Laurentiu Mogoanta, Professor, MD, PhD; e-mail: laurentiu_mogoanta@yahoo.com

DOI: 10.47162/RJME.61.1.23 Download PDF