The immunoexpression of p53 and Snail in endometrioid endometrial carcinomas

Vol. 59 No. 1, 2018


Mihaela Dragomirescu, Alex Emilian Stepan, Claudiu Margaritescu, Cristiana Eugenia Simionescu

Endometrial cancer is one of the most common tumors in women worldwide. P53 has a well-known function as tumor suppressor, but it can also regulate the tissues metabolism, differentiation and development. Snail is a zinc-finger transcription factor, involved in the cell differentiation and survival. We analyzed the immunoexpression of p53 and Snail in 55 cases of endometrioid endometrial carcinoma (EEC), in relation with the histopathological prognosis parameters and tumoral compartments, respectively intratumoral and advancing edge areas. For both markers, we found a statistically significant association with histological grade, in relation with tumoral compartments. P53 and Snail can be used in developing EEC targeted treatment.

Corresponding author: Alex Emilian Stepan, Associate Professor, MD, PhD; e-mail:

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