Cribriform-morular variant of papillary thyroid carcinoma at pediatric age - case report and review of the literature

Vol. 57 No. 2 Suppl., 2016
This supplement was not sponsored by Outside Organizations.


Andreea Cristiana Brehar, Dana Cristina Terzea, Dumitru Lucian Ioachim, Camelia Procopiuc, Felix Mircea Brehar, Alexandra Catalina Bulgar, Mircea Vasile Ghemigian, Constantin Dumitrache

Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is a rare tumor, which exceptionally occurs at pediatric age. CMV-PTC may develop in patients with familial adenomatous polyposis (FAP) or may be a sporadic tumor. The authors present a case of CMV-PTC in a 10-year-old girl patient without FAP history, who presented with a left neck mass. The patient underwent total thyroidectomy with central compartment neck dissection. Histopathological diagnosis was compatible with cribriform-morular variant of papillary thyroid carcinoma and Hashimoto s thyroiditis. Immunostaining was positive for thyroglobulin, beta-catenin, CD10 and p53. Molecular test showed the absence of BRAF, K-RAS mutations, deletions or duplications of APC (adenomatosis polyposis coli) gene and showed the presence of RET/PTC (rearranged during transfection/papillary thyroid carcinoma) rearrangements. At 32 months follow-up, the patient was without signs of recurrence. This particular form of thyroid carcinoma should raise suspicion of a possible familial cancer syndrome, therefore early diagnosis and thoroughly evaluation, which includes colonoscopy and genetic screening are mandatory.

Corresponding author: Felix Mircea Brehar, Assistant Professor, MD, PhD; e-mail:

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Elvira Bratila, Oana-Maria Ionescu, Dumitru-Cristinel Badiu, Costin Berceanu, Simona Vladareanu, Doina Mihaela Pop, Claudia Mehedintu

Endometriosis is a gynecologic condition affecting mainly the pelvic organs. However, extrapelvic endometriosis has been reported in almost all parts of the body. Umbilical endometriosis, either primary or secondary, is uncommon and has a documented neoplastic risk. We present the case of a 46-year-old woman with a large umbilical hernia associating primary umbilical endometriosis discovered during surgery and confirmed later by pathological and immunohistochemical exams. The patient underwent omphalectomy and partial omentum resection, alongside with mesh abdominal wall repair. The patient was informed about the recurrence risk and was asymptomatic at follow-up consults.

Corresponding author: Costin Berceanu, University Lecturer, MD, PhD; e-mail:

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