Multifunctional materials such as MCM-41/Fe3O4/folic acid as drug delivery system

Vol. 57 No. 2 Suppl., 2016
This supplement was not sponsored by Outside Organizations.


Simona Popescu, Ioana Lavinia Ardelean, Dragos Gudovan, Marius Radulescu, Denisa Ficai, Anton Ficai, Bogdan Stefan Vasile, Ecaterina Andronescu

In this study, MCM-41 mesoporous silica nanoparticles (NPs) and MCM-41/Fe3O4 mesoporous silica NPs were prepared by sol-gel method using CTAB (cetyltrimethylammonium bromide) as template and TEOS (tetraethyl orthosilicate) as silica precursor in order to use these materials as drug delivery system (DDS) for different biologically active agents. The MCM-41 and MCM-41/Fe3O4 mesoporous silica NPs were characterized using specific physico-chemical methods [transmission electron microscopy (TEM), scanning electron microscopy (SEM), nitrogen adsorption and desorption studies - BET (Brunauer-Emmett-Teller) method, X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy], while the release studies were done by a high-performance liquid chromatography (HPLC)-modified method. The pH dependence of the delivery of folic acid from the mesoporous structures was analyzed and found that the release is pH sensitive. The lower delivery at strongly acid pH comparing with neutral/slightly alkaline pH could be beneficial because in stomach the folic acid can be destroyed.

Corresponding author: Denisa Ficai; e-mail:

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Ileana Octavia Petrescu, Viorel Biciusca, Citto Iulian Taisescu, Dragos Ovidiu Alexandru, Oana Taisescu, Maria Victoria Comanescu, Florin Petrescu, Iulian Alin Silviu Popescu, Diana-Maria Trasca, Mircea Catalin Fortofoiu, Cristian Adrian Silosi, Maria Fortofoiu

In chronic hepatitis, pathologies reveal a prominent inflammatory infiltrate portal consisting mostly of lymphocytes and plasma cells invading the portal spaces, although one can also identify macrophages, neutrophils or eosinophils. In all the forms of chronic hepatitis, fibrosis starts in the portal area, namely periportally, subsequently extends towards the lobules to the central veins, causing septa, followed by fibrosis. We studied 52 patients with chronic hepatitis C, who underwent a hematological, biochemical, virological and histopathological investigation. We found that the severity degree of the portal inflammation was in direct relation to the hepatitis activity index (HAI) and to the degree of fibrosis. The portal inflammation is dependent to the degree of fibrosis. The degree of inflammation significantly changes the distribution of cases with different degrees of fibrosis (chi-square p=0.00011 <0.001). Periportal inflammation, periportal necrosis and focal necrosis are the morphological aspects of the necroinflammatory process best correlated to the occurrence and development of fibrosis.

Corresponding author: Citto Iulian Taisescu, Associate Professor, MD, PhD; e-mail:

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