The molecular mosaic of the premalignant cutaneous lesions

Vol. 57 No. 2 Suppl., 2016
This supplement was not sponsored by Outside Organizations.


Doinita Olinici, Laura Gheuca-Solovastru, Laura Stoica, Laurentiu Badescu, Pavel Onofrei, Emanuela Ana Botez, Carmen Elena Cotrutz

In the last three decades, the premalignant cutaneous lesions have represented a milestone for the clinicians and the anatomopathologists given the increased risk of malignant transformation not only in the old but also in the young population. Recent research indicates the fact that, though multiple progresses were recorded in the diagnosis and treatment of the cutaneous squamocellular carcinomas, developed in more than 85% of the cases in premalignant lesions, however the prognosis and survival up to five years did not register significant improvements. For the achievement of the diagnosis with certainty, the histopathological examination, considered until recently the golden standard, principally based on the TNM criterion, has an increased percentage of subjectivity and it is relatively unsure, being known the fact that two apparently identical tumors answer differently to the same therapy. The variability of the morphological aspects from simple dysplasia to in situ carcinomas and the cancers themselves impose the identification of some cellular and molecular markers typical to the premalignant and malignant cutaneous lesions. In this respect, the knowledge and characterization of the molecular mosaic allow the establishment of some clear criterion for an early diagnosis, corresponding monitoring and adequate treatment.

Corresponding author: Carmen Elena Cotrutz, Professor, MD, PhD; e-mail:

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Adriana-Mihaela Ciocalteu, Elena Tatiana Cartana, Dan Nicolae Florescu, Ioana-Andreea Gheonea, Ionut Madalin Troponete, Tudorel Ciurea, Dan Ionut Gheonea

Conventional white light endoscopy is far from being an ideal tool to detect, characterize, and confirm the nature of colorectal lesions in order to indicate targeted biopsies or polyp resections only when necessary. Minimally invasive imaging techniques have gradually emerged to reveal previously unseen abnormalities to the operator during endoscopic examination. In this respect, technology and applications of narrow band imaging (NBI) are rapidly evolving. Magnification using NBI with near-focus mode has been introduced recently to enable closer examination under the control of a single button. The aim of this article is to offer an in-depth overview of this topic with emphasis on colorectal polyps through a literature review by using PubMed search tools including full-text articles, up-to-date guidelines and recent abstracts with obvious conclusions.

Corresponding author: Ioana-Andreea Gheonea, Associate Professor, MD, PhD; e-mail:

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