Overexpression of CSF-1R in nasopharyngeal carcinoma

Vol. 56 No. 4, 2015

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Li Huang, Ximing Xu, Yanrong Hao, Jiaxin Chen, Lei Li, Junping Cheng, Zhaohong Chen, Wuqing Liang, Jiao Yang, Wen Ao, Xin Hao, Weiwei Gao

Background: Tumor-associated macrophages play a significant role in tumor progression. CSF-1/CSF-1R is one of the most primary regulators of macrophage physiology in immune system. The expression of CSF-1/CSF-1R in nasopharyngeal carcinoma is unclear. Objectives: The aim of this study was to compare the expression of CSF-1R in nasopharyngeal carcinoma to nasopharyngitis for assessing the role CSF-1/CSF-1R in nasopharyngeal carcinoma. Materials and Methods: Diagnostic tissues from 56 nasopharyngeal carcinoma patients and 32 nasopharyngitis patients were evaluated retrospectively by immunohistochemical analysis for the expression of CSF-1R. Results: Significant differences of CSF-1R expression exists between nasopharyngeal carcinoma patients and nasopharyngitis patients (p<0.001). However, there is no relevance between CSF-1R and worse survival.

Corresponding author: Ximing Xu, Archiater; e-mail: whuxxm@yahoo.com; Yanrong Hao, Associate Senior Doctor; e-mail: yanronghao.2008@aliyun.com

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