Efficiency of gentamicin loaded in bacterial polysaccharides microcapsules against intracellular Gram-positive and Gram-negative invasive pathogens

Vol. 56 No. 4, 2015

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Cristina Doina Croitoru, Dan Eduard Mihaiescu, Mariana Carmen Chifiriuc, Alexandra Bolocan, Coralia Bleotu, Alexandru Mihai Grumezescu, Crina Maria Saviuc, Veronica Lazar, Carmen Curutiu

Gentamicin is an aminoglycoside antibiotic with a wide spectrum of anti-bacterial activity, but however, due to its high solubility in water, it poorly penetrates inside the cells. This major inconvenient constitutes an important challenge for the treatment of intracellular bacterial infections, which might be solved using appropriate delivery systems for the targeted release of the bioactive agents at the intracellular sites of infection. Thus, in the case of antibiotics, the use drug delivery systems may contribute to increase their therapeutic activity against intracellular pathogens. This paper presents an efficient polymeric delivery system for the intracellular release of gentamicin based on bacterial polysaccharides.

Corresponding author: Dan Eduard Mihaiescu, Chem. Eng., PhD; e-mail: danedmih@gmail.com

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