Carbon nanotubes for cancer therapy and neurodegenerative diseases

Vol. 56 No. 2 Suppl., 2015
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Elena Daniela Melita, Gabriela Purcel, Alexandru Mihai Grumezescu

Our review summarizes the latest approaches regarding a new class of nanomaterials - carbon nanotubes (CNTs) -, which are promising candidates in different areas of nanomedicine. This paper discusses the main applications of CNTs in the repair of injured nerves and also as delivery systems for cancer therapy in difficult to reach anatomic sites. In terms of neurological applications, we focus on neural interface, neural stimulation, microelectrodes, and differentiation of stem cell into neural cells. Also, we highlight the in vitro and in vivo applications of CNTs-mediated cancer therapy and we will explain why CNTs are used for the treatment of difficult tumors.

Corresponding author: Alexandru Mihai Grumezescu, Chem. Eng., PhD; e-mail: grumezescu@yahoo.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Anca Livia Chirita, Victor Gheorman, Dan Bondari, Ion Rogoveanu

Depression is highly prevalent worldwide and associated with significant morbidity and mortality. Approximately 340 million people worldwide suffer from depression at any given time. Based on estimates from the World Health Organization (WHO), depression is responsible for the greatest proportion of burden associated with non-fatal health outcomes and accounts for approximately 12% total years lived with disability. Probably no single risk factor can be completely isolated in major depressive disorder (MDD), as interactions between many sources of vulnerability are the most likely explanation. Buttressing the identification of grief, demoralization, hopelessness and styles of psychological coping of the depressed patient are vital, ongoing scientific developments that flow from an increased understanding of this interplay amongst the immune system, endocrine system and brain. The rapidly accumulating body of neurobiological knowledge has catalyzed fundamental changes in how we conceptualize depressive symptoms and has important implications regarding the treatment and even prevention of depressive symptoms in patients.

Corresponding author: Victor Gheorman, MD, PhD student; e-mail: victor_gheorman1@yahoo.com

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