Desmosomes as markers for the proliferating parietal epithelial cells in collapsing glomerulosclerosis. A case report

Vol. 55 No. 2 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Eugen Mandache, Simona Stancu, Gener Ismail, Mircea Penescu

Two variants of focal segmental glomerulosclerosis are known to present epithelial hypercellularity in the Bowman s space, namely the collapsing and the cellular types. This epithelial cell proliferation may get features of either pseudocrescent or tubular profiles. Our case of collapsing focal segmental glomerulosclerosis has been ultrastructurally investigated concerning the proliferating epithelial cell type: parietal versus visceral. Based on the cellular organelles, especially on the ubiquitous presence of desmosomes, the authors are endorsing, with ultrastructural arguments, the opinion favoring the parietal epithelial cells (PEC) as the proliferating cell type. It is also taken into consideration the eventual change of PECs phenotype in contact with the glomerular tuft components like the glomerular basement membrane.

Corresponding author: Eugen Mandache, MD, PhD; e-mail:

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Cristian Funieru, Bogdan Banica, Cristian-Niky Cumpata, Ruxandra Ionela Sfeatcu, Adina Mihaela Dumitrache, Mihaela Raescu, Ionela Teodora Dascalu, George Simion, Mihaela Jana Tuculina

Purpose: The purpose of this paper is to present a rare case of osteoma localized in the left frontal sinus. A 22-year-old woman who arrived at the Department of Neurosurgery of the University Emergency Hospital, Bucharest, Romania, presented a vertical asymmetry of the eyeballs but displayed no clinical signs like pain or diplopia. The computer tomography exam was used for preoperatory diagnostic. Histopathology was performed after surgery using Hematoxylin and Eosin staining. The Nikon Eclipse microscope was used to examine the slides. Results: The histopathology exam shows a compact osteoma with dense and non-Haversian bone tissue and parallel bony trabeculae. A few spaces for the marrow were also found. The osteocytes were small and no fibrous cells were discovered. Conclusions: The computer tomography and histopathology exam were the investigations that lead us to a true diagnostic of dense osteoma. This tumor was the first case of frontal sinus osteoma histologically described in the Romanian population.

Corresponding author: Mihaela Raescu, Associate Professor, DMD, PhD; e-mail:

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