Coexistence of renal cell carcinoma of clear cell type with sarcomatoid cell type component and adrenal mature ganglioneuroma with myelolipoma - a case of 69-year-old female patient

Vol. 55 No. 2 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Piotr Lewitowicz, Andrzej Wincewicz, Agata Horecka-Lewitowicz, Jaroslaw Matykiewicz, Dorota Koziel, Stanislaw Gluszek, Stanislaw Sulkowski

This report presents a case of 69-year-old woman, who was operated due to renal tumor. Apart from renal neoplasm, the adjacent adrenal gland contained another one tumor in medulla of the organ. The renal lesion was diagnosed renal cell carcinoma, clear cell type with undifferentiated cell sarcomatoid component. The adrenal neoplasm was composed of wavy S100-positive, Schwann-like cells and dispersed chromogranin A-reactive ganglion cells to be consistent with mature ganglioneuroma. It was accompanied by coexistent myelolipoma that contained hematopoietic cells including clearly visible megakaryocytes and foci of fat. To our knowledge, our paper is the first to report sporadic clear cell renal cell carcinoma with sarcomatoid cell type component and mature adrenal ganglioneuroma with myelolipoma in the same patient.

Corresponding author: Andrzej Wincewicz, FEBP, MD, PhD; e-mail:,

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Serban Rosu, Carmen Neamtu, Bogdan Totolici

Normally present in the temporal region, the juxtaoral organ of Chievitz has considerable importance for both the surgeon and the pathologist. Although very rare, the nodular hyperplasia of the Chievitz s organ has been misinterpreted as invasive carcinoma. The pathological aspect mimics the mucoepidermoid carcinoma, squamous carcinoma, basal cell carcinoma with sebaceous differentiation or tumor of the skin appendages. We present the case of a 71-year-old patient admitted with temporal tumor. The initial pathological diagnosis was mixed squamous basal cell carcinoma. The subsequent evaluation of sections and immunohistochemistry allowed us to demonstrate a benign tumor of the Chievitz s organ. In this case, therapy and prognosis are strongly related to the correct diagnosis and avoid an over treatment of a benign tumor._x000D_

Corresponding author: Serban Rosu, University Assistant, MD, PhD; e-mail:

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