Inflammatory pseudotumors of the kidney due to IgG4-related tubulointerstitial nephritis

Vol. 55 No. 2 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Mihai Harza, Gener Ismail, George Mitroi, Mihaela Gherghiceanu, Adrian Preda, Ioanel Sinescu

The paper presents the case of a female patient who was admitted to our department because of prolonged febrile syndrome, altered general status and renal tumoral masses revealed by thoracic and abdominal CT. After thorough histological examination, including immunohisto-chemistry and in situ hybridization studies, we reached the diagnosis of renal pseudotumoral masses due to IgG4-related tubulointerstitial nephritis. The kidney is a distinct target organ affected by IgG4-related sclerosing disease, and the most frequent manifestation is tubulo-interstitial nephritis. We described the clinical, imagistic and histopathological features of kidney and urological involvement in IgG4-related sclerosing disease, especially focusing on IgG4-related tubulointerstitial nephritis. This is a rare case of IgG4-related sclerosing disease without extrarenal features, excepting lumboaortic lymphadenopathy.

Corresponding author: Gener Ismail, MD, PhD; e-mail:

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Ionica Pirici, Otilia Margaritescu, Daniela Cernea, Loredana Elena Stoica, Calin-Gabriel Sarla, Daniel Pirici

Basal cell carcinoma is the most common malignant tumor of the skin, and it develops most frequently on the head and neck regions. Although most of these tumors are slow growing and with a limited evolution, the existence of some aggressive variants accompanied by a complete neglect from the patient may occasionally lead to invasion of the face and organs of the head and neck. Even though, intracranial invasion of basal cell carcinoma of the scalp is a rare presentation. We describe here the case of a woman who developed an aggressive and neglected morpheiform basal cell carcinoma (ulcus terebrans), which showed a complete invasion through the skull, but with an apparent self-limitation to the pia mater._x000D_

Corresponding author: Daniel Pirici, Lecturer, MD, PhD; e-mail:

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