Cutaneous verrucous carcinoma - report of three cases with review of literature

Vol. 55 No. 2 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Mariana Costache, Laura Tatiana Desa, Luminita Elena Mitrache, Oana Maria Patrascu, Adrian Dumitru, Diana Costache, Emanuel Albu, Maria Sajin, Olga Simionescu

Verrucous carcinoma is a rare variant of squamous cell carcinoma. It is well differentiated and rarely metastases but can sometimes be very aggressive locally in depth. The paper presents three cases of cutaneous verrucous carcinoma with different localizations. The first patient shows a lesion in the sacrogluteal region, the second one presented a tumor localized on the auricle (external ear), and the third patient showed a tumor on the sole of the foot. All patients underwent tumor excision and the histopathological diagnosis was verrucous carcinoma. In the first two cases, the surgery was completely curative by excision of the tumors. In the last case, the patient had relapsed and due to the aggressive nature of the tumor, which infiltrated the deeper plans, the tumor had reached the bone. None of the patients showed any metastases.

Corresponding author: Mariana Costache, Associate Professor, MD, PhD; e-mail:

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Cristian Mesina, Ion Vasile, Daniela Ciobanu, Firmilian Calota, Corina Lavinia Gruia, Liliana Streba, Stelian Stefanita Mogoanta, Horia Parvanescu, Claudia Valentina Georgescu, Danut Nicolae Tarnita

Collision tumors of the colon are rare. A 64-year-old man was referred on Emergency County Hospital, Craiova, Romania for the evaluation of intestinal obstruction. Colonoscopy demonstrates the presence of about 9/5 cm sized mass in the rectosigmoid junction. After surgical resection, the rectosigmoid lesion was histopathologically composed of two distinct lesions: mucoid adenocarcinoma in the superficial layer and poorly differentiated neuroendocrin carcinoma in the deeper layer. A rectosigmoid tumor showed two distinct tumors with no admixture or transposition of two neoplastic components. A lymph node metastatic deposit contained both tumors. Immunohistochemical stainings were consistent with mucinous adenocarcinoma and neuroendocrine carcinoma of the two neoplasms. We report this case of colonic collision tumor (mucoid adenocarcinoma and neuroendocrine carcinoma) and review of the literature.

Corresponding author: Daniela Ciobanu, Lecturer, MD, PhD; e-mail:

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