Magnetite nanostructures functionalized with cytostatic drugs exhibit great anti-tumoral properties without application of high amplitude alternating magnetic fields

Vol. 55 No. 2 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Georgeta Voicu, Livia Elena Crica, Oana Fufa, Lavinia Iuliana Moraru, Roxana Cristina Popescu, Gabriela Purcel, Miruna Codruta Stoilescu, Alexandru Mihai Grumezescu, Coralia Bleotu, Alina Maria Holban, Ecaterina Andronescu

Here, we report the synthesis, characterization and the impact of magnetite nanoparticles functionalized with cytostatic drugs, epirubicin (Epi) and fludarabine (Flu) (Fe3O4@Epi, Fe3O4@Flu) prepared by chemical co-precipitation method on tumoral cells in vitro. The average diameter of the resulted particles was about 4 nm for both Fe3O4@Epi and for Fe3O4@Flu. These bioactive nanostructured materials proved to significantly enhance the antitumor effect of tested cytostatic drugs in vitro. The most significant result was obtained in the case of Epi, where the tested magnetite nanostructured material enhanced the cytotoxic effect of this drug with more than 50%.

Corresponding author: Alexandru Mihai Grumezescu, Chem. Eng., PhD; e-mail:

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Izabella Petre, Roxana Folescu, Onut Bacean, Anca Bordianu, Ioana Mihaela Luca, Elena Bernad, Marius Lucian Craina

The placental development is a complex process, in which any disturbance can induce changes with grave consequences for the offspring. Villi and villous vascularization development is in, and underdevelopment can lead to villous placental insufficiency. This paper aims to analyze the arterial and venous vasculature of the placenta, both macroscopic and morphologically, by different injection techniques of contrast agents (plastic substances type AGO II) in 50 human placentas with different ages of gestation.

Corresponding author: Elena Bernad, Assistant Professor, MD, PhD; e-mail:

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