Liver steatosis associated with chronic hepatitis C

Vol. 55 No. 2 Suppl., 2014
This supplement was not sponsored by Outside Organizations.


Eugenia Irimia, Laurentiu Mogoanta, Ion Octavian Predescu, Ion-Cristian Efrem, Casiana Stanescu, Letitia Adela Maria Streba, Anca Meda Georgescu

Hepatic steatosis is a common histological finding in chronic liver diseases. One of the pathological entities in which hepatic steatosis has been found is chronic hepatitis C. The prevalence of steatosis in these patients ranges from 40% to 86%, with an average of 55%, which is two times higher than the steatosis seen in adults uninfected with hepatitis C. Many studies have shown that hepatic steatosis is a medical condition that may progress to steatohepatitis, progressive hepatic failure, hepatic cirrhosis, and is a risk factor for development of hepatocellular carcinoma. We have proposed to evaluate the severity of steatosis in patients with chronic hepatitis C and to correlate it with necroinflammatory processes and fibrosis. We included 259 patients diagnosed with chronic hepatitis C and proven histological steatosis. Age of patients with hepatic steatosis varied from 20 to 69 years. Most cases of steatosis associated with chronic hepatitis C (47.87%) were diagnosed in the age group 50-59 years. Of 259 patients, 141 (54.44%) were female and 118 (45.56%) male. Slight steatosis was identified in 130 cases (50.19%), moderate fatty changes were present in 54 (20.85%) patients and severe steatosis in 75 (28.96%) patients. The appearance of steatosis was macrovesicular and predominantly affected the third zone of the hepatic lobe. Most cases of hepatic steatosis were associated with necroinflammatory activity and low and moderate fibrosis. Cases of marked steatosis associated with intense activity accounted for about 10%, while marked steatosis was associated with severe fibrosis in less than 5% of cases.

Corresponding author: Letitia Adela Maria Streba, Associate Professor, MD, PhD; e-mail:

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Horatiu Pompiliu Petrescu, Gabriel Dinu, Gheorghe Noditi, Marcel Berceanu-Vaduva, Dana Cristina Bratu, Dinu Vermesan

Bone is the second tissue in terms of number of transplants after blood. There is an increased trend of incidence of severe bone lesions with comminuted fractures, with significant lack of substance, as well as an increased incidence of cancer types combined with therapeutic advances in recent decades, allowing for large surgical interventions that affect the bones and create significant defects in bone and contribute to the overall increase in the number and complexity of bone transplants. Autografts may be used singly or in various combinations, with significantly better effects than other implant materials. Use of autografts is limited by complications from the receptor site, mainly related to infections and undetectable necrotic areas on initial microscopic examination, which prevent proper incorporation of autografts, but also those of the donor situs. The aim of the study was to assess the integration of tibial bone grafts into the femur of Wistar rats by radiologic exam and histological evaluation. We concluded that the fixing of the graft to the host tissue may be subject to some microenvironment influences. The presence of the periosteum on the grafts is certainly an asset during transplantation. We confirm once again that the ability of transplanted periosteum of osteoformation and reactivation. Our observations regarding the contribution of bone marrow endorse the view of its active role in bone formation.

Corresponding author: Horatiu Pompiliu Petrescu, Assistant Professor, MD, PhD; e-mail:

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