Histopathology of the nail unit

Vol. 55 No. 2 Suppl., 2014
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Angel Fernandez-Flores, Marcela Saeb-Lima, Alfonso Martinez-Nova

In this report, we review several inflammatory infectious and tumoral conditions of the nail unit. We emphasize the anatomic peculiarities of such pathologies of the nail unit and provide some required diagnostic criteria.

Corresponding author: Angel Fernandez-Flores, MD, PhD; e-mail: dermatopathonline@gmail.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Li Huang, Ximing Xu, Yanrong Hao

CSF-1/CSF-1R (colony-stimulating factor-1/colony-stimulating factor-1 receptor) is the primary growth factor regulating the survival, proliferation, and differentiation of cells of the mononuclear phagocytic lineage. Multiple studies have demonstrated that CSF-1/CSF-1R plays a certain role in tumor tissues. CSF-1 binding to CSF-1R through the class III RTKs leads to a series of signal molecules responding to CSF-1 via various signaling pathway. Through these pathways, all signal molecules would promote development of tumor directly or contribute to progress of various cancers indirectly by increasing tumor-associated macrophages, for instance promoting tumor growth, angiogenesis, extracellular matrix breakdown, invasion, and metastasis. Thus, in this paper, we analysis multiple experimental results comprehensively, making a review about the mechanism of CSF-1/CSF-1R promoting tumor progression.

Corresponding author: Ximing Xu, Archiater, Master s Supervisor; Yanrong Hao, Associate Senior Doctor, Master s Supervisor; e-mail: whuxxm@yahoo.com, yanronghao.2008@aliyun.com

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