Microanatomic aspects of arterial blood supply in rectal carcinomas - predictive models

Vol. 54 No. 3 Suppl., 2013
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

M. V. Hinganu, Delia Hinganu, L. L. Francu

Rectum is divided into three distinctive regions (pelvic peritoneal, pelvic subperitoneal and perineal) regarding the regions where it is crossing through. Those three parts are individually not only due to their relation but due to their blood supply, also. The differences occur among them when one of them is involved into a neoplastic process. Both types of pelvic rectal tumors behave quite in the same way but those involving perineal rectum are much different. This is because they purchase a smaller number of anastomosis; when a tumor monopolizes a wide vessel the possibility to grow and become a metastasis is much more likely. These two processes (growth and metastasis) are directly related to the size of its supplying artery. On the other hand, a pelvic rectal tumor is more likely to metastasis by blood flow then a perineal rectal one. The last one will rather send clone cells by lymphatic drainage or will disseminate into the soft tissues around it. In this study, we want to propose an anatomical mathematical model for each of the rectal tumors, depending on their stages also. We used specimens from 24 patients and analyzed them using arteriography; we connected the results of mathematical counting of micro vessels density in a specific area with already known medical aspects regarding their diagnosis, treatment and evolution. The goal of the study concerns the prognosis of the patients (with or without surgical treatment) and the example is useful in rectal tumors staging.

Corresponding author: Delia Hinganu, MD, PhD; e-mail: delia_f24@yahoo.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

C. C. Nistor-Ciurba

To evaluate the correlations between patient, tumor and therapeutic features and DCIS recurrence after primary treatment, a cohort of 132 cases of DCISs, treated at "Prof. Dr. Ion Chiricuta" Oncology Institute, Cluj-Napoca, Romania, between 1999 and 2010, were studied. Present study showed that age <45 years at diagnosis and presence of the necrosis were significantly correlated with recurrence, meanwhile nuclear grade is significantly correlated with quicker relapse meaning that for high-grade lesions recurrence occurs usually during the first 36 months of follow-up, meanwhile for non-high-grade lesions recurrence usually occurs after 36 months of follow-up. Also, the study showed that a important factor correlated with recurrence (both local and overall) for patients treated with breast conservative surgery (BCS) was the status of the resection margins as well as the association of adjuvant radiotherapy. Overall recurrence rate was 9.(84)% and during a mean follow-up of 62.99 months with limits between 24 (imposed by study) and 153 months, standard deviation 29.28.

Corresponding author: Codrut Cosmin Nistor-Ciurba, MD; e-mail: nistorco@yahoo.com

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