MRI diagnosis of perivascular epithelioid cell tumor (PEComa) of the liver

Vol. 54 No. 3 Suppl., 2013
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Hua-qiang Sheng, Dong-feng Chen, Xin-hai Sun, Xian Li, Jie Xu, Xi-bin Hu, Mei-Qin Li, Tao Wu, Ren-ya Zhang, Kai-zhi Li

Introduction: Perivascular epithelioid cell tumor (PEComa) has been rarely reported in the liver. Patient, Methods and Results: We present a liver PEComa case diagnosed by magnetic resonance imaging (MRI) findings. The patient was incidentally found to have an abnormal mass in the liver. MRI revealed early and strikingly homogeneous enhancement of the lesion. Partial hepatectomy was performed, and a pathological examination revealed signs of typical of PEComa. The patient was closely monitored for 12 months after the surgery, with no clinical or radiographic evidence of recurrence or metastatic disease. Conclusion: MRI diagnosis is applicable for PEComa.

Corresponding author: Hua-qiang Sheng, Professor; e-mail: huaqiang_sheng@163.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Monica Costescu, Oana Andreia Coman, M. Tampa, Irina Tudose, L. Coman, Simona Roxana Georgescu

Basal cell carcinoma (BCC) is the most common cutaneous cancer. It seems that the most important prognostic factor is exposure to ultraviolet radiation (solar and artificial), correlated with other factors as well. In this article, we aimed to review basal cell carcinoma located in the axilla, referring to cases from our hospital. Axillary location of BCC is rare, with a very low number of cases quoted in the literature, compared to the high prevalence of basal cell carcinoma in the general population. During a period of two years, we detected only four cases of axillary basal cell carcinoma out of a total number of 921 cases diagnosed as BCC. We were interested in identifying certain factors involved in causing BCC, post-excision clinical evolution, histological type and aggressiveness of axillary basal cell carcinoma. Therefore, we quantified objectively the tumor and stromal expression of some immunological markers like: metalloproteinases MMP1, 3, 11, Ber-EP4 and Ki67. Histological types of tumors investigated here belong to the category of non-aggressive BCC, namely as nodular and superficial, although Ki67 index is greater than the average reported in the literature for this type of tumor. MMPs exhibited increased expression in tumors and stromal compartments, especially at the tumor invasion front, and was not associated with tumor ulceration or surrounding tissue remodeling-related changes. Our results confirm the literature data concerning the involvement of MMPs in BCC progression, whatever the tumor location is.

Corresponding author: Monica Costescu, MD, PhD; e-mail: monica.costescu@yahoo.com

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