Dental pulp as a stem cell reservoir

Vol. 54 No. 3 Suppl., 2013
This supplement was not sponsored by Outside Organizations.


Andreea Cristiana Didilescu, M. C. Rusu, G. Nini

Currently, much information is provided regarding the presence and the roles in tissue regeneration of stem cell niches residing in post-natal dental pulp. So far, three types of adult stem cells have been isolated from dental pulp. Correct evaluation of these cells is important in order to determine their potential use in clinical fields. The present study aims to review the origins and immunophenotype of these cells. The particularities of interstitial cells of the stem cell niches are also debated.

Corresponding author: Mugurel Constantin Rusu, Senior Lecturer, MD, PhD; e-mail:

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A. Fernandez-Flores

Recently, it has been demonstrated how apocrine glands, as well as several cutaneous apocrine tumors, do not express calretinin. In the current report, we studied calretinin immunoexpression in 33 cases of cutaneous metastases of ductal breast carcinoma, as well as in seven primary cutaneous apocrine tumors. We also tested the hormonal status of all cases for estrogen receptors (ER), progesterone receptors (PR), and ERRB2. From the 33 metastases, 26 (78.79%) cases were calretinin-negative and seven cases expressed the marker. Five (15.15%) cases were triple-negative (ER-, PR-, Herceptest-). Of these five cases, three cases were calretinin+ and two cases were calretinin-. Three out of the seven cases that expressed calretinin were triple-negative. From the seven primary cutaneous apocrine tumors, only one showed focal expression of calretinin, and six of them showed a triple-negative immunophenotype. Only the ER+, PR+ case showed morphologic features on an "in situ" apocrine carcinoma. We concluded that our findings support the value of calretinin in the differential diagnosis between a metastasis from breast carcinoma into the skin and a primary cutaneous apocrine carcinoma (CAC), especially in triple-negative cases. However, hormonal markers plus calretinin would not be sufficient to discriminate between both diagnostic possibilities, and they are probably better used when integrated in a wide immunohistochemical panel.

Corresponding author: Angel Fernandez-Flores, MD, PhD; e-mail:

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