Hairy cell leukemia - a rare type of leukemia. A retrospective study on 39 patients

Vol. 54 No. 3 Suppl., 2013
This supplement was not sponsored by Outside Organizations.


Amelia Maria Gaman

Hairy cell leukemia (HCL) is a chronic B-cell lymphoid leukemia characterized by pancytopenia, splenomegaly, myelofibrosis and the presence in peripheral blood, bone marrow and spleen of atypical lymphoid cells with a hairy aspect. This is a retrospective analysis of 39 patients hospitalized in the Clinic of Hematology, "Filantropia" Municipal Hospital, Craiova, Romania, between 1997-2012, devised by age, sex, and HCL type. Characteristic features of diagnosis (including clinical features, laboratory data: complete blood cell count, differential count, peripheral blood and bone marrow infiltration with atypical lymphoid cells with cytoplasm fine prolongations, immunophenotyping of peripheral blood, bone marrow, spleen or lymph node biopsies with histopathological exams and immunohistochemistry), types of therapy (focused on IFN-alpha), complications (infections, hemorrhage, autoimmune, second malignancies) and survival rate were monitored. Conclusions of the study revealed the importance of histopathology and immunohistochemistry for diagnosis, of the therapeutic options in the absence of purine nucleoside analogues, the most frequent complications and the decrease of their incidence correlated with therapy and increased count of neutrophils.

Corresponding author: Amelia Maria Gaman, Associate Professor, MD, PhD; e-mail:

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V. Nimigean, Vanda Roxana Nimigean, Lavinia Butincu, D. I. Salavastru, L. Podoleanu

Objective: In this study, we mapped the topography of the greater palatine foramen (GPF), within the South-Eastern European population, according to clinically identifiable anatomical landmarks. Materials and Methods: We used 100 dry adult human skulls, of which 75 were bilaterally dentate, whereas 25 were partially edentulous. Results: The shape of the GPF was oval in 84% of the cases. The foramen was located internally from the third molar in 73% of the skulls. The greater palatine canal showed an antero-infero-medial direction in 82% of the cases. The average values of the distances between the GPF and the oral surfaces of the maxillary third molar, the medio-palatine suture, the posterior margin of the hard palate, the pterygoid hamulus and the pterygo-maxillary suture were 11.0 (SD 1.5), 14.5 (SD 0.8), 4.4 (SD 1.1), 12.0 (SD 1.8) and 10.5 mm (SD 1.3), respectively. Conclusions: A thorough knowledge of GPF's various positions may assist the clinicians in providing improved surgical techniques in the area.

Corresponding author: Vanda Roxana Nimigean, Senior Lecturer, PhD; e-mail:

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