Immunohistochemical expression of EGF, c-erbB-2 and EGFR in intestinal variant of gastric adenocarcinomas

Vol. 54 No. 3 Suppl., 2013
This supplement was not sponsored by Outside Organizations.


Anca Oana Docea, P. Mitrut, Daniela Cernea, C. C. Georgescu, D. Olimid, Cl. Margaritescu, Daniela Dumitrescu

In this study, we aimed to determine EGF, c-erbB-2 and EGFR expression in 25 specimens of intestinal gastric adenocarcinomas by standardized immunohistochemistry and to establish correlations with the major clinico-morphological parameters of these patients. We observed EGF reactivity in 22 (88%) cases, a c-erbB-2 protein expression in eight (32%) cases and an EGFR reactivity in 13 (46.42%) cases. The EGF expression was significantly correlated with the tumor degree of differentiation, but not with other investigated clinico-morphological parameters and nor with c-erbB-2 and EGFR1 expression. However, we noticed the existence of a dependence between c-erbB-2 and EGFR1 expression in the main tumor mass. Such immunoprofile suggests the possible intervention of autocrine and paracrine loops in the developing of intestinal variant of gastric adenocarcinomas.

Corresponding author: Claudiu Margaritescu, Associate Professor, MD, PhD; e-mail:

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L. L. Francu, Delia Hinganu, M. V. Hinganu

The face, seen as a unitary region is subject to the gravitational force. Since it is the main relational and socialization region of each individual, it presents unique ways of suspension. The elevation system of the face is complex, and it includes four different elements: the continuity with the epicranial fascia, the adhesion of superficial structures to the peri- and inter-orbital mimic muscles, ligaments adhesions and fixing ligaments of the superficial layers to the zygomatic process, and also to the facial fat pad. Each of these four elements were evaluated on 12 cephalic extremities, dissected in detail, layer by layer, and the images were captured with an informatics system connected to an operating microscope. The purchased mesoscopic images revealed the presence of a superficial musculo-aponeurotic system (SMAS) through which the anti-gravity suspension of the superficial facial structures become possible. This system acts against face aging and all four elevation structures form what the so-called sustentaculum facies. The participation of each of the four anatomic components and their approach in the facial rejuvenation surgeries are here in discussion.

Corresponding author: Marius Valeriu Hinganu, MD, PhD; e-mail:

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