Immune-complex deposits in pANCA glomerulonephritis: a pediatric case report

Vol. 54 No. 2, 2013

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Mihaela Balgradean, Eliza Cinteza, E. Mandache

A 15-year-old boy is admitted to the hospital for clinical signs that suggest a pulmonary-renal syndrome (fever, cough, hemopthoic expectoration, oliguria, gross hematuria). A crescentic pANCA positive glomerulonephritis was configured. However, dense subendothelial deposits were identified in electronic microscopy and immunofluorescence staining showed granular deposits of IgG and C3, kappa and lambda in the capillary loops. Although the treatment was strictly followed, after three years and three months of good clinical state, he manifested signs of kidney failure being transplanted. His case represents a specific pattern of rapidly progressive glomerulonephritis leading to kidney failure and emphasizes the importance of clinical attendance especially in a case of two associated glomerulopathies.

Corresponding author: Eliza Cinteza, MD, PhD; e-mail: elizacinteza@yahoo.com

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