Cervical adenocarcinoma: a retrospective clinicopathologic study of 16 cases

Vol. 53 No. 3 Suppl., 2012
This supplement was not sponsored by Outside Organizations.


Ileana Barbu, Stefania Craitoiu, Cl. Margaritescu

Endocervical adenocarcinomas account for about 10-30% of cancers of the uterine cervix and display a variety of disparate morphologies. As an objective of the present work, we analyzed the clinicopathologic characteristics and prognostic factor of cervical adenocarcinoma. Clinicomorphological data of 16 cases of endocervical adenocarcinoma were reviewed during 2006-2011. Histopathologically, seven cases were of mucinous endocervical type, one intestinal type, two mucinous villoglandular type, four endometrioid type and two of serous type. The immunohistochemical investigation showed a tipically endocervical carcinoma profile ER-/PR-/Vim-/CEA+ in 10 cases (62.5%), which morphologically corresponded to: five mucinous endocervical type, one villoglandular type, three endometrioid type and one serous type. Regarding the prognosis we established that endometrioid endocervical adenocarcinoma is the histological variant with the worst prognosis, most cases been diagnosed in advanced stages (IIIA and IIIB) while at the opposite pole were papillary villoglandular and serous endocervical adenocarcinomas, diagnosed in less advanced stages of disease (IB and IIB). We concluded that the clinicomorphological diagnosis of endocervical adenocarcinoma is a challenging task, given to its multitude of histological variants and to the fact that immunohistochemistry investigations proved to be useful in only 63% of cases. In addition, we confirmed that the clinical stage is the most important prognostic factor and to some extent, the histomorphologic features can condition the biological behavior of these tumors.

Corresponding author: Claudiu Margaritescu, Associate Professor, MD, PhD; e-mail: c_margaritescu2000@yahoo.com

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S. S. Mogoanta, C. Mesina, Liliana Streba, Anca Predescu, Garofita Olivia Mateescu, Gabriela Mutiu, L. Mogoanta

Ectopic bone formation in the digestive tract is a very rare phenomenon in pathology. Most cases of bone metaplasia were found in distal colon tumors, rectum and sigmoid respectively. We present a case of well-differentiated adenocarcinoma of the caecum (the second case of literature) associated with bone metaplasia, which debuted atypical, with symptoms of infectious enterocolitis, in a 72-year-old female patient, with no history of digestive pathology. Highlighting bone metaplasia was achieved by current histological techniques. Patient's evolution was favorable with surgical treatment and chemotherapy.

Corresponding author: Laurentiu Mogoanta, Professor, MD, PhD; e-mail: laurentiu_mogoanta@yahoo.com

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