Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor

Vol. 53 No. 3 Suppl., 2012
This supplement was not sponsored by Outside Organizations.


Luminita Daguci, A. Stepan, Veronica Mercut, C. Daguci, Marilena Bataiosu, Alma Florescu

Our study included a number of 24 cases with Warthin tumor, diagnosed between 2007-2011, which were analyzed in terms of clinical, histopathological and immunohistochemistry point of view, using CK7, CK5/6, CK19, and p63 antibodies. Warthin tumor is most often a tumor with a slow evolution, painless, usually affecting males (M/F 3.2/1) in the seventh decade of life. Histopathologically, it is distinguished the predominance of the typical forms of the tumor, with a balanced ratio epithelium/stroma. The immunostaining for CK7 showed positivity in all the investigated cases both in the columnar luminal cells and basal cells. The immunostaining for CK5/6 was positive in all the investigated cases in bilayer epithelial basal cells, both in the structure of the cysts and the papillae. In the case of the immunostaining for p63 we noticed limited nuclear positivity in the basal cells, while the columnar cells' nucleus were negative. The immunohistochemical study of the bilayer epithelial component of Warthin tumor showed different immunstaining of the two types of epithelia, the oncocytary columnar and the basal on, similar to those found in the salivary gland ducts.

Corresponding author: Alex Stepan, University Assistant, MD, PhD candidate; e-mail:

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Mihaela Dinu, Raluca Niculina Ciurea, Mirela Stefan, Ana Claudia Georgescu

Identification of the origin of neoplastic pleural effusion is a major concern in lung pathology. This study followed the diagnostic role of a panel of antibodies that included calretinin, HBME1, D2-40, Ber-EP4, CK5/6, CEA and TTF1, in a total of 37 cases of pleural and lung cancer with tumor-type cytology, later confirmed by histopathology. For mesothelioma, positive staining for calretinin, D2-40 and CK5/6 and negative for CEA and TTF1 were characteristic. For lung adenocarcinomas, we found Ber-EP4, CEA and TTF1 positivity, and calretinin, D2-40 and CK5/6 negativity. Squamous lung carcinomas were positive for Ber-EP4, CK5/6 and CEA and negative for HBME1, D2-40 and TTF1. The panel of antibodies used in this study provides a differential diagnosis between mesotheliomas and lung carcinomas as well as between lung adenocarcinomas and squamous carcinomas.

Corresponding author: Raluca Ciurea, University Assistant, MD, PhD; e-mail:

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