The vasculogenesis - a possible histological identification criterion for the molar pregnancy

Vol. 52 No. 1 Suppl., 2011
This supplement was not sponsored by Outside Organizations.


Liliana Novac, Mihaela Niculescu, Maria Magdalena Manolea, D. Iliescu, Claudia Valentina Georgescu, Al. Comanescu, N. Cernea, Andreea Enache

The benign hydatidiform mole (partial and complete) practically represents an associated pathology of the first trimester miscarriage; it is considered that it represents the initial pathology, which, evolutionally, may be followed by the appearance of invasive mole and choriocarcinoma. The authors have studied clinical and cytogenetical 61 cases selected according to some specific criteria for the suspicion of molar pregnancy or hydropic abortion and 21 cases that represented the control group made by patients with normal pregnancy which have been presented for legal abortion. In all cases has been made a histological exam and has been studied the vasculogenesis by immunohistochemistry labeling for CD31 and CD34. Following-up the results has been established a number of histological and immunohistochemical criteria for the evaluation and differentiation of various molar pregnancy types and the vasculogenesis characteristics. The most important differential diagnosis criteria between partial and complete mole is represented by the trophoblast disposition and the atypical trophoblast in the complete mole.

Corresponding author: Liliana Novac, Professor, MD, PhD, e-mail:

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I. E. Plesea, D. Anusca, Simona Bondari, O. T. Pop, F. Poenaru, V. Dascalu, Mirela Ghilusi

Periprosthetic bone changes following hip arthroplasty are yet to be completely described. The material consisted of imagistic records (X-ray films, CT and MRI scans) and of acetabular bone tissue sampled from 14 cases with femoral head prosthesis and revision of the prosthesis fixed and decalcified in Duboscq-Brazil solution and stained with Hematoxylin and Eosin, trichrome van Gieson and trichrome Masson. Acetabular bone is home of a great variety of morphological changes that can be divided in degenerative and regenerative changes seen in both compact and trabecular components but only inside the maximal pressure area of the acetabular roof. Our preliminary morphological study revealed the existence of an adaptation effort to the mechanical stress materialized through a dynamic process of bone remodeling in the maximal pressure area.

Corresponding author: Iancu Emil Plesea, Professor, MD, PhD, e-mail:

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