Aberrant TTF-1 expression in papillary high-grade urothelial neoplasm: case report and literature review

Vol. 52 No. 1 Suppl., 2011
This supplement was not sponsored by Outside Organizations.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Maria J. Fernandez-Acenero, S. Cordova, C. Santonja

We herein report the case of a 48-year-old man who developed synchronous advanced tumors in the lung and the bladder. The most striking feature of our case is that the otherwise typical bladder urothelial carcinoma showed focal areas (comprising less than 5% of the tumor mass) of nuclear positivity for TTF-1 (thyroid transcription factor-1). The different pattern of cytokeratin expression led us to consider them two independent primary tumors. Several recent reports have indicated that the type of clone used can influence the results of TTF-1 staining and can explain positivity in extrapulmonary and extrathyroid tumors.

Corresponding author: Maria J. Fernandez-Acenero, MD, PhD, e-mail: mgg10167@gmail.com

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ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Ana-Maria Dragan, Elena Rosca, Gabriela Mutiu

The classification of squamous cell carcinomas, based on cellular differentiation features, includes the poorly differentiated epidermoid carcinomas and well-differentiated epidermoid carcinomas. The histogenetic cytologic data clarify conventional cytodiagnosis of poorly differentiated epidermoid carcinomas and poorly differentiated adenocarcinoma, and also eliminate other categories such as large cell carcinoma and small cell anaplastic carcinoma. We conducted a study for evaluating the degree of differentiation of pulmonary squamous cell carcinoma in 620 patients - 551 men (88.8%) and 69 women (11.1%) who had lung cancer confirmed by cytologic, histologic and bronchoscopic examination. The cytologic examination was performed on slides with samples obtained by bronchial brushing and prints of bronchial biopsy stained with the Giemsa method. Histopathologic examination was performed on samples obtained by bronchial biopsy and stained with Hematoxylin-Eosin. At cytologic examination we found: poorly differentiated epidermiod carcinomas in 66 cases (33.8%), moderately differentiated epidermoid carcinomas in 22 cases (11.2%) and well differentiated epidermoid carcinomas in 107 cases (54.8%). Histological examination revealed: poorly differentiated epidermoid carcinomas in 133 cases (45.7%), moderately differentiated epidermoid carcinomas in 32 cases (10.9%), and well differentiated epidermoid carcinomas in 126 cases (43.2%). Our results suggested the importance of the association between cytologic and histopatologic examinations in the diagnosis of lung cancer.

Corresponding author: Ana-Maria Dragan, Associate Professor, MD, PhD, e-mail: dragan_21_noiembrie@yahoo.com

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