Value of immunohistochemical investigation in the diagnosis of neuromuscular diseases in children

Vol. 52 No. 1 Suppl., 2011
This supplement was not sponsored by Outside Organizations.


D. Matei, I. Gherghina, Eliza Cinteza, A. Matei, Marilena Alexianu

Neuromuscular diseases represent an important group in pediatric pathology. Immunohistochemistry together with clinical examination and morphologic exam are very important in the diagnosis of neuromuscular disorders. Patients and Methods: One hundred children diagnosed with neuromuscular disorders were included in a prospective-retrospective study in 25 years. Results: There were 58 neurogenic diseases and 42 muscular dystrophies. In positive and differential diagnosis very important were the morphologic and immunohistochemical investigations. Seventy-three percent had positive family history and 27% of dystrophic patients had "de novo" mutations. The most part of the neurogenic disorders were spinal motor atrophies, 91.38%. Conclusions: Neurogenic muscular diseases were the most common neuromuscular diseases in our patient group. The immunohistochemical investigation was very useful in diagnosing some of these cases.

Corresponding author: Dumitru Matei, Professor, MD, PhD, e-mail:

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Oana Pobirci, Fl. Bogdan, D. D. Pobirci, Elena Rosca, Carmen Adina Petcu

Introduction: The examination of the synovial is very useful in the positive and differential diagnostic of many articular diseases and especially in the conditions of acute monoarthritis. Materials and Methods: The study focused on the establishment of clinical-statistical, histopathological and immunohistochemical correlations on a group of cases anatomo-pathologic diagnosed with synovity with articular inflammatory liquid. The group was divided in five subgroups: rheumatoid polyarthritis, uric arthropathy (gout), TBC arthritis, sarcoidosis and villo-nodular synovity. Results and Discussion: During the clinical-statistical study the number of arthritis with articular inflammatory infiltration was pursued, the specific location of them and the correlation of the clinical dates with paraclinical ones. In the histopatological and immunohistochemical analysis was pursued the presence of the inflammatory infiltration through the implication of both types of B- and T-lymphocytes in different proportions taking into consideration the cause of the synovity. Conclusions: The synovial biopsy is indicated at patients at whom the diagnostic is not established after the clinical evaluation. The examination of the synovial tissue can be the only way of establishing a definitive diagnostic in inflammatory arthropathies.

Corresponding author: Florin Bogdan, Professor, MD, PhD, e-mail:

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