Clinical and histoenzymatic interrelations of the edentulous ridge's mucosa

Vol. 52 No. 1 Suppl., 2011
This supplement was not sponsored by Outside Organizations.


Monica Mihaela Craitoiu, Mihaela Pauna, Stefania Craitoiu, Veronica Mercut

The edentulous ridge's mucosa presents various histological aspects and different histoenzymatic equipment. These aspects are determined by constitutional factors (genetic, nutritional), as well as by age and by the associated pathology. The purpose of this paper is to evidentiate, through histochemical techniques, the aerobe (NADH2-cytochrome-c reductase) and anaerobe (lactatdehydrogenase) oxidoreducing enzymatic activities, as well as the hydrolytic enzyme's activity (ATP-ases, pH 9.4), corroborated with the histological aspects of the edentulous ridge's mucosa. The enzymatic activity and the morphological alterations present various aspects, depending on the metabolic type (aerobe oxidative, anaerobe oxidative, hydrolytic), according to the mucosal area (epithelium, chorion), to the different cell types, or even within the same cellular type (especially at the level of the connective lamina propria cells). They also vary from one edentulous patient to another, depending on the existence of a previous prosthetic treatment and on the type of this treatment. The local clinical examination, sustained by a histoenzymatic investigation, reveals the importance of the structural alterations and they can offer guidance for the proper prosthetic treatment and for the achievement of functional prosthetic restorations that provide the oral mucosa its necessary trophicity for as long as possible.

Corresponding author: Monica Mihaela Craitoiu, Assistant Professor, DMD, PhD candidate, e-mail:

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Fl. Marcu, Fl. Bogdan, Gabriela Mutiu, L. Lazar

The osteoporosis is characterized by the imbalance between the activity of the osteoblasts, the bone forming cells, and the osteoclasts, the cells that resorb the bone tissue, imbalance that favors the osteoclasts. As a conclusion, in the case of osteoporosis, for the same volume, the bone is less compact and more fragile. The objective of our study is to make a histological evaluation of the different elements of the bone tissue in many 47 bone samples: 27 bone fragments were collected from the head and the femoral head of patients who required hip arthroplasty and 20 bone fragments were collected from the vertebral body of dead patients. The results of our study emphasized the thinned trabeculae of the bone that lost continuity, the preferential resorption of the horizontal trabeculae, the consecutive trabecular anisotropy and the reduction of the trabecular connectivity with enlarged areolae and the adipose degeneration of the marrow. One notices in the osteoporosis a reduction of the trabecular network connectivity directly proportional with the stage of the illness; thus, we determined a strong reduction of the trabecular connectivity in advanced osteoporosis stages. The growth aspects of the medular adiposity, associated with the intratrabecular connectivity concurs to highlight the functional connection between bone and marrow. The diminution of the medullar cellularity together with its enrichment in fat cells has negative outcomes on the bone.

Corresponding author: Florin Marcu, Assistant Professor, e-mail:

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