Dowling-Degos disease

Vol. 51 No. 1, 2010

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

E. F. Georgescu, Ligia Stanescu, Carmen Florina Popescu, Maria Comanescu, Iuliana Georgescu

Dowling-Degos disease (DDD) is a rare autosomal dominant inherited pigmentary disorder of the flexures with a reticulate aspect and with presence of prominent comedone-like lesions and pitted scars. The diagnosis includes acanthosis nigricans as well as other reticulate pigmentary disorders classified into: dyschromatrosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH) and reticulate acropigmentation of Kitamura (RAPK). We present a 35-year-old woman, which presented with flexural hyperpigmentation considerate as acanthosis nigricans. At a close clinical and histopathological examination, we obtained sure data for Dowling-Degos disease, with a possible familial history of this disease in her son. We review the literature data concerning this disease.

Corresponding author: Eugen Florin Georgescu, Professor, MD, PhD, e-mail: efg@usa.net

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