Cytokines levels in prostate adenocarcinomas

Vol. 46 No. 3, 2005

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

Maria Balasoiu, Adriana Turculeanu, Carmen Avramescu, Violeta Comanescu, Cristiana Simionescu, L. Mogoanta

In this research, we determined the levels of IL-2, IL-6 and TNF-alpha at 60 patients with prostate adenocarcinomas situated in II, III and IV stages. The method used was ELISA quantitative. We observed that the IL-2 levels were normal in II stage, and the levels of IL-6 and TNF-alpha were lightly increased. In III and IV stages of prostate cancer, the levels of IL-2 were very low and the levels of IL-6 and TNF-alpha were very increased. The high levels of pro-inflammatory cytokines are correlated with diseases evolution. The decrease of IL-2 levels in advanced prostate cancer goes to the decrease of immune response in prostate cancer.

Corresponding author: Maria Balasoiu, MD, PhD, e-mail: turculeanu_balasoiu@yahoo.com

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